Elaine J. Schattner, MD
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0184.
Schattner EJ. Supplemental Ultrasonography Screening for Women With Dense Breasts. Ann Intern Med. 2015;162:802. doi: 10.7326/L15-5061-3
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Published: Ann Intern Med. 2015;162(11):802.
TO THE EDITOR:
Sprague and colleagues (1) used 3 simulations to assess the benefits, harms, and cost-effectiveness of supplemental ultrasonography screening in women with dense breasts. Each calculation incorporates assumptions that decrease the validity of the findings. The primary analysis involves a hypothetical population of women aged 50 to 74 years, but dense breasts predominantly affect younger women. Extremely dense breasts—the condition for which the authors' models consistently found the greatest benefit—are unusual after menopause. For this reason, among women for whom breast cancer screening might be advisable, the most relevant cohort is those aged 40 to 55 years.
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