Alain Braillon, MD, PhD; Susan Bewley, MD
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0625.
Braillon A, Bewley S. Behavioral Counseling and Pharmacotherapy Interventions for Tobacco Cessation in Pregnant Women. Ann Intern Med. 2016;164:637. doi: 10.7326/L15-0625
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Published: Ann Intern Med. 2016;164(9):637.
TO THE EDITOR:
With its “review of reviews” for the U.S. Preventive Services Task Force, Patnode and colleagues (1) failed to critically analyze a recent negative trial (2) and missed a major well-designed trial on nicotine replacement therapy (NRT) (3).
The authors included a trial of low-dose nicotine patches alone (16 mg of nicotine delivered over 16 hours) that unsurprisingly failed to decrease withdrawal symptoms and craving versus placebo (2), because pregnant women are highly dependent on nicotine due to increased metabolism (4).
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