Craig R. Walsh, MD; Martin G. Larson, ScD; Jane C. Evans, DSc, MPH; Luc Djousse, MD, MPH; R. Curtis Ellison, MD; Ramachandran S. Vasan, MD; Daniel Levy, MD
Grant Support: By contract N01-HC-38038 from the National Heart, Lung, and Blood Institute and grant AR/AG 41398 from the National Institutes of Health. Dr. Vasan was supported in part by a research career award 1K24 HL04334 from the National Heart, Lung, and Blood Institute.
Requests for Single Reprints: Daniel Levy, MD, Framingham Heart Study, 5 Thurber Street, Framingham, MA 01702.
Current Author Addresses: Drs. Walsh, Larson, Evans, Vasan, and Levy: Framingham Heart Study, 5 Thurber Street, Framingham, MA 01702.
Drs. Djousse and Ellison: Preventive Medicine, Room B-612, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118.
Author Contributions: Conception and design: C.R. Walsh, M.G. Larson, J.C. Evans, D. Levy.
Analysis and interpretation of the data: C.R. Walsh, M.G. Larson, J.C. Evans, R.C. Ellison, R.S. Vasan, D. Levy.
Drafting of the article: C.R. Walsh, R.C. Ellison, R.S. Vasan, D. Levy.
Critical revision of the article for important intellectual content: C.R. Walsh, M.G. Larson, L. Djousse, R.C. Ellison, R.S. Vasan, D. Levy.
Final approval of the article: C.R. Walsh, L. Djousse, R.C. Ellison, R.S. Vasan, D. Levy.
Statistical expertise: M.G. Larson.
Collection and assembly of data: L. Djousse.
Although excessive alcohol consumption can promote cardiomyopathy, little is known about the association between alcohol consumption and risk for congestive heart failure in the community.
To determine the relation between alcohol consumption and risk for congestive heart failure in the community.
Community-based, prospective observational study.
Participants in the Framingham Heart Study who were free of congestive heart failure and coronary heart disease.
Self-reported alcohol consumption; sex-specific rates of congestive heart failure per 1000 person-years of follow-up by level of alcohol consumption.
In men, 99 cases of congestive heart failure occurred during 26 035 person-years of follow-up. In women, 120 cases of congestive heart failure occurred during 35 563 person-years of follow-up. After adjustment for multiple confounders, risk for congestive heart failure was lower among men at all levels of alcohol consumption compared with men who consumed less than 1 drink/wk. The hazard ratio for congestive heart failure was lowest among men who consumed 8 to 14 drinks/wk (0.41 [95% CI, 0.21 to 0.81]) compared with those who consumed less than 1 drink/wk. In women, the age-adjusted hazard ratio for congestive heart failure was lowest among those who consumed 3 to 7 drinks/wk (0.49 [CI, 0.25 to 0.96]) compared with those who consumed less than 1 drink/wk. However, after adjustment for multiple predictors of congestive heart failure, this association was no longer statistically significant.
In the community, alcohol consumption is not associated with increased risk for congestive heart failure, even among heavy drinkers (≥ 15 drinks/wk in men and ≥ 8 drinks/wk in women). To the contrary, when consumed in moderation, alcohol appears to protect against congestive heart failure.
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Walsh CR, Larson MG, Evans JC, Djousse L, Ellison RC, Vasan RS, et al. Alcohol Consumption and Risk for Congestive Heart Failure in the Framingham Heart Study. Ann Intern Med. 2002;136:181–191. doi: 10.7326/0003-4819-136-3-200202050-00005
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Published: Ann Intern Med. 2002;136(3):181-191.
Cardiology, Heart Failure, Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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