JACK H. LADENSON, Ph.D.; FRED S. APPLE, Ph.D.; DAVID D. KOCH, Ph.D.
Serum from patients with hyperlipemia has been clearly shown to have low sodium values when analyzed by flame photometry (1-10). This artifactually low sodium value is due to a decrease in the percentage of water (water content) in serum or plasma. This decrease in water content leads to less sodium in a given volume aliquot of the sample taken for analysis even though the "concentration" of sodium in the water phase may be unaltered. Methods for measuring sodium in serum include the traditional technique of flame photometry or the more recent and increasingly used technique of potentiometry using a sodium
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LADENSON JH, APPLE FS, KOCH DD. Misleading Hyponatremia Due to Hyperlipemia: A Method-Dependent Error. Ann Intern Med. 1981;95:707-708. doi: 10.7326/0003-4819-95-6-707
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Published: Ann Intern Med. 1981;95(6):707-708.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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