Jane Durga, PhD; Petra Verhoef, PhD; Lucien J.C. Anteunis, PhD; Evert Schouten, PhD; Frans J. Kok, PhD
Acknowledgments: The authors thank all study participants for their time and motivation; the Folic Acid and Carotid Intima-media Thickness (FACIT) trial research team for their dedication and enthusiasm; Mickey Chenault, University Hospital Maastricht and Heinsius Houbolt Foundation, for data verification; and Martijn Katan, Wageningen University and Wageningen Centre for Food Sciences, for critical comments on the manuscript.
Grant Support: By the Netherlands Organisation for Health Research and Development (ZonMw, grant no. 20010002), Wageningen University, and Wageningen Centre for Food Sciences.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Jane Durga, PhD, Cognitive Sciences Group, Nutrition & Health Department, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Durga: Cognitive Sciences Group, Nutrition & Health Department, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland.
Dr. Verhoef: Nutrition Department, Unilever–UFHRI, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands.
Dr. Anteunis: Department of Otorhinolaryngology, Division of Audiology, Brain, and Behavior Institute, University Hospital Maastricht, 6200 MD Maastricht, The Netherlands.
Dr. Schouten: Food and Consumer Product Safety Authority, PO Box 19506, 2500 CM The Hague, The Netherlands.
Dr. Kok: Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.
Author Contributions: Conception and design: J. Durga, L.J.C. Anteunis, E. Schouten.
Analysis and interpretation of the data: J. Durga, L.J.C. Anteunis, E. Schouten.
Drafting of the article: J. Durga, L.J.C. Anteunis, E. Schouten.
Critical revision of the article for important intellectual content: J. Durga, P. Verhoef, L.J.C. Anteunis, F.J. Kok.
Final approval of the article: J. Durga, P. Verhoef, L.J.C. Anteunis, E. Schouten, F.J. Kok.
Provision of study materials or patients: J. Durga.
Statistical expertise: J. Durga.
Obtaining of funding: J. Durga, P. Verhoef, E. Schouten, F.J. Kok.
Administrative, technical, or logistic support: J. Durga, P. Verhoef.
Collection and assembly of data: J. Durga, E. Schouten.
Durga J, Verhoef P, Anteunis LJ, Schouten E, Kok FJ. Effects of Folic Acid Supplementation on Hearing in Older Adults: A Randomized, Controlled Trial. Ann Intern Med. 2007;146:1-9. doi: 10.7326/0003-4819-146-1-200701020-00003
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Published: Ann Intern Med. 2007;146(1):1-9.
Hearing loss is one of the most common chronic conditions of elderly persons, and age-related hearing loss is the most common type of hearing impairment (1). Age-related hearing loss refers to a sensorineural hearing loss due to aging and other physiologic, environmental, and pathologic processes that occur throughout the lifespan (2). Factors that vary with age, such as the increase in plasma total homocysteine concentrations, may play an etiologic role in age-related hearing loss. Folate is an important dietary determinant of plasma total homocysteine concentrations (3, 4), and folic acid supplementation can lower those levels by approximately 25% (5).
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