Andrew S. Levey, MD; Josef Coresh, MD, PhD; Frederick Van Lente, PhD
Potential Financial Conflicts of Interest: None disclosed.
Levey AS, Coresh J, Van Lente F. Estimated Glomerular Filtration Rate. Ann Intern Med. 2007;146:74-75. doi: 10.7326/0003-4819-146-1-200701020-00021
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Published: Ann Intern Med. 2007;146(1):74-75.
Dr. Delanaye and colleagues question whether the precision of the creatinine assay within the reference range is sufficient for accurate GFR estimation. The Beckman Synchron CX3 assay used during the MDRD Study had analytic CVs of 4.3% and 1.5% at creatinine values of 88.4 µmol/L (1.0 mg/dL) and 477.3 µmol/L (5.4 mg/dL), respectively (1). The enzymatic assay used to calibrate the MDRD Study laboratory to standardized creatinine had analytic CVs of 2.0% and 1.8% at creatinine values of 78.7 µmol/L (0.89 mg/dL) and 518.0 µmol/L (5.86 mg/dL), respectively, in 2004 (n = 194) and 1.6% and 1.1% at creatinine values of 88.4 µmol/L (1.00 mg/dL) and 339.5 µmol/L (3.84 mg/dL), respectively, in 2005 (n = 409). Thus, the analytic CV for the enzymatic assay is as low as or is lower than that stated by Dr. Delanaye and colleagues.
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