Lorenzo Dagna, MD; Fulvio Salvo, MD; Mirta Tiraboschi, MD; Enrica P. Bozzolo, MD; Stefano Franchini, MD; Claudio Doglioni, MD; Angelo A. Manfredi, MD; Elena Baldissera, MD; Maria Grazia Sabbadini, MD
Acknowledgment: The authors thank Annalisa Capobianco for performing the PTX3 enzyme-linked immunosorbent assay.
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-0375.
Reproducible Research Statement:Study protocol, statistical code, and data set: Available from Dr. Dagna (e-mail, firstname.lastname@example.org).
Requests for Single Reprints: Lorenzo Dagna, MD, Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milano, Italy; e-mail, email@example.com.
Current Author Addresses: Drs. Dagna, Salvo, Tiraboschi, Bozzolo, Franchini, Baldissera, and Sabbadini: Unit of Medicine and Clinical Immunology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milano, Italy.
Dr. Doglioni: Department of Pathology, San Raffaele Scientific Institute, Via Olgettina 58, I-20132 Milano, Italy.
Dr. Manfredi: Autoimmunity and Vascular Inflammation Unit, San Raffaele Scientific Institute, Via Olgettina 58, I-20132 Milano, Italy.
Author Contributions: Conception and design: L. Dagna, F. Salvo, E.P. Bozzolo, E. Baldissera, M.G. Sabbadini.
Analysis and interpretation of the data: L. Dagna, F. Salvo, E.P. Bozzolo, S. Franchini, C. Doglioni, A.A. Manfredi, E. Baldissera, M.G. Sabbadini.
Drafting of the article: L. Dagna, F. Salvo.
Critical revision of the article for important intellectual content: L. Dagna, S. Franchini, E. Baldissera, M.G. Sabbadini.
Final approval of the article: L. Dagna, F. Salvo, E.P. Bozzolo, S. Franchini, E. Baldissera, M.G. Sabbadini.
Provision of study materials or patients: L. Dagna, E. Baldissera, M.G. Sabbadini.
Statistical expertise: L. Dagna.
Collection and assembly of data: L. Dagna, F. Salvo, M. Tiraboschi, E.P. Bozzolo, S. Franchni, C. Doglioni, A.A. Manfredi, E. Baldissera.
Dagna L., Salvo F., Tiraboschi M., Bozzolo E., Franchini S., Doglioni C., Manfredi A., Baldissera E., Sabbadini M.; Pentraxin-3 as a Marker of Disease Activity in Takayasu Arteritis. Ann Intern Med. 2011;155:425-433. doi: 10.7326/0003-4819-155-7-201110040-00005
Download citation file:
Published: Ann Intern Med. 2011;155(7):425-433.
Because pentraxin-3 (PTX3) is produced by immune and vascular cells in response to proinflammatory signals, it may be a useful biomarker for defining disease activity in patients with Takayasu arteritis.
To compare PTX3 levels in patients who have Takayasu arteritis with those in healthy and infected controls, and to compare accuracy of PTX3 levels with that of C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) for distinguishing active and inactive disease.
Cross-sectional, noninterventional study conducted between September 2005 and October 2008.
Immunology and rheumatology clinic at a university hospital in Italy.
57 consecutive patients with Takayasu arteritis and known disease activity, 57 healthy blood donor controls, and 15 patients with acute infection.
Disease activity by clinical criteria; plasma PTX3 and CRP levels and ESR.
27 patients had active Takayasu arteritis; 30 had inactive disease. Levels of PTX3 were higher in patients with active disease (median, >2.14 ng/mL [range, 0.57 to 48.18 ng/mL]) than in those with inactive disease (median, 0.63 ng/mL [range, 0.00 to 1.64 ng/mL]) and were higher than in healthy patients (median, 0.11 ng/mL [range, 0 to 1.20 ng/mL]) or those with acute infection (median, 0.26 ng/mL [range, 0 to 0.75 ng/mL]). A plasma PTX3 level greater than 1 ng/mL was more accurate than normal thresholds of CRP or ESR for distinguishing active from inactive disease.
The study excluded patients with unknown or equivocal disease status.
Plasma levels of PTX3 could help distinguish active from inactive Takayasu arteritis but should not be adopted for clinical use until the findings are confirmed in a broader spectrum of patients whose disease activity is unknown or equivocal before testing.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only