Anita K. Wagner, PharmD, MPH, DrPH; Dennis Ross-Degnan, ScD; Stephen B. Soumerai, ScD; Jerry H. Gurwitz, MD
Potential Financial Conflicts of Interest: None disclosed.
Wagner A., Ross-Degnan D., Soumerai S., Gurwitz J.; Benzodiazepines and Hip Fractures. Ann Intern Med. 2007;147:348. doi: 10.7326/0003-4819-147-5-200709040-00017
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Published: Ann Intern Med. 2007;147(5):348.
Dr. Lesser supports our conclusion of the possible lack of a relationship between the use of benzodiazepines and hip fractures in the elderly with additional data from the published literature. Since the landmark studies of 1987 (1) and 1989 (2), results of research on the benzodiazepine–hip fracture relationship have become increasingly contradictory. We concur with Dr. Lesser that differences in results are probably due to study design issues, such as benzodiazepine exposure misclassification in prospective cohort studies (3) and imperfect control for potential confounders in large, claims data–based, case–control studies (4). On the basis of these results and our study, we believe that broad-based policies, such as the payment restrictions encompassed in Medicare Part D, which are in part based on these controversial results, are misdirected.
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