Suetonia C. Palmer, MBChB; Jonathan C. Craig, PhD; Giovanni F.M. Strippoli, PhD
Potential Financial Conflicts of Interest: None disclosed.
Palmer S., Craig J., Strippoli G.; Vitamin D Compounds in Chronic Kidney Disease. Ann Intern Med. 2008;148:970. doi: 10.7326/0003-4819-148-12-200806170-00014
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Published: Ann Intern Med. 2008;148(12):970.
Like Dr. Scissors, our preference is for clinical practice to be based on randomized, controlled trials. We also recognize that until the required trials are performed, a sensible approach to distilling existing data and informing practice should be used. However, we need to emphasize that our inclusion criteria were not limited to stage V chronic kidney disease and that we searched for trials of any vitamin D compound, including generic over-the-counter products. No trial data were available on the effects of these products, and very few biochemical data were available on any product in stage III or IV chronic kidney disease. Until these trials are performed, we would be more circumspect than Dr. Scissors and suggest that use of these products for this indication may not be safe.
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