HERBERT Z. GIFFIN, M.D.; EDGAR V. ALLEN, M.D.
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Since 1918, when Eppinger and Kloss (1) first introduced phenylhydrazine in the treatment of polycythemia vera, an increasing number of reports from the clinical standpoint have been recorded, notably those of Owen (2) and Brown and Giffin (3). Notwithstanding the excellence of these reports, certain fundamental questions in connection with the effect of the drug remain unanswered. This is due to the difficulty of keeping in touch with patients over long periods and more particularly to the impossibility of subjecting them to the rigid research methods which can be conveniently carried out on animals.
The experimental work on animals has
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GIFFIN HZ, ALLEN EV. Experiments With Phenylhydrazine: I. Studies On the Blood(I. Studies On the Blood*). Ann Intern Med. 1928;1:655–676. doi: 10.7326/0003-4819-1-9-655
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Published: Ann Intern Med. 1928;1(9):655-676.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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