JOSEPH B. WOLFFE, M.D.; DONALD FINDLAY, Ph.D.; EDWARD DESSEN, M.D.
In 1926 E. K. Frey and H. Kraut1 found a substance in the urine which they demonstrated to have vasodilator properties, and which they believed to be a circulation hormone (Kreislaufhormon). In 1929 Frey2 operated on a patient who had a pancreatic cyst and found that the cystic fluid was rich in this particular hormone. They have since studied this product extensively and have come to the following conclusions:
1. The hormone is present in the blood and is excreted in the urine.
2. The hormone is present in the blood mainly in an inactivated form and excreted in the
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WOLFFE JB, FINDLAY D, DESSEN E. Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary Report(Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary Report*†)(Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary Report*†). Ann Intern Med. 1931;5:625–642. doi: 10.7326/0003-4819-5-5-625
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Published: Ann Intern Med. 1931;5(5):625-642.
Cardiology, Coronary Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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