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Two certain and two doubtful cases of the Lawrence-Moon-Biedl syndrome are reported, and are combined with 73 acceptable cases from the literature in a tabular analysis of this extremely interesting complex. The six cardinal symptoms―obesity, genital dystrophy, retinitis pigmentosa, mental deficiency, polydactylism, and familial occurrence―are by no means all invariably present. Such groupings as obesity, genital dystrophy, and retinitis pigmentosa; obesity, mental deficiency, and retinitis pigmentosa; and retinitis and polydactylism, are encountered. Unless the complete syndrome is present, familial occurrence is necessary for positive diagnosis. In the reported cases there are 25 with complete findings. Some authors have found symptomatic
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Lawrence-Moon-Biedl Syndrome.. Ann Intern Med. 1932;6:587. doi: 10.7326/0003-4819-6-4-587_1
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Published: Ann Intern Med. 1932;6(4):587.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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