JAMES F. RINEHART, M.D.
On the basis of experimental data previously reported1, 2 the concept was presented that rheumatic fever may be the result of the combined influence of vitamin C deficiency and infection. It is the purpose of this communication briefly to review this and to summarize further confirmatory experimental observations and other data accumulated during the past three years that would appear to support this thesis.
Experimental Method. The methods employed are essentially similar to those reported.1, 2 Guinea pigs were maintained on a basic diet adequate in all food factors except vitamin C. Regulating the intake of vitamin C by giving
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RINEHART JF. STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL, AND GENERAL CONSIDERATIONS(STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL, AND GENERAL CONSIDERATIONS*I. RHEUMATIC FEVER): I. RHEUMATIC FEVER. Ann Intern Med. 1935;9:586–599. doi: 10.7326/0003-4819-9-5-586
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Published: Ann Intern Med. 1935;9(5):586-599.
Infectious Disease, Rheumatoid Arthritis, Rheumatology, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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