EINAR R. DANIELS, M.D.; WILLIAM S. MIDDLETON, M.D., F.A.C.P.
Clinical studies of the action of thevetin1, 2 have amply confirmed the pharmacologic results of Chen and Chen3, 4 and established its reliable digitalis-like effect in man. The pulse is slowed, evidences of decompensation are alleviated, diuresis ensues and characteristic electrocardiographic changes occur when thevetin is given either by the oral or the parenteral route. Its untoward by-effects also parallel those of digitalis with a singular deviation in the gastrointestinal action. Here intestinal effects (cramps and diarrhea) in the main replace the common gastric upsets (anorexia, nausea and vomiting) incident to digitalis intoxication.
The galenical preparations of the defatted be-still
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DANIELS ER, MIDDLETON WS. CLINICAL EXPERIENCES WITH REDUCED DOSES OF THEVETIN ORALLY ADMINISTERED(CLINICAL EXPERIENCES WITH REDUCED DOSES OF THEVETIN ORALLY ADMINISTERED*). Ann Intern Med. 1936;10:505–513. doi: 10.7326/0003-4819-10-4-505
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Published: Ann Intern Med. 1936;10(4):505-513.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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