SAMUEL S. ALTSHULER, M.D., F.A.C.P.
Since the discovery of insulin by Banting and Best,1 unremitting effort has been put forth toward the improvement of the product. One of the lines of endeavor has been to make insulin purer by crystallization.
Insulin was first crystallized by Abel2, 3, 4 in 1926. He prepared it from highly purified commercial preparations. Howard and DeLawder5 were the first to determine whether this crystalline insulin could be used therapeutically in human beings for the treatment of diabetes mellitus. Four diabetic patients were carefully regulated on diets and standard insulin; then crystalline insulin was substituted for standard in equivalent doses. They
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ALTSHULER SS. THE CLINICAL USE OF CRYSTALLINE INSULIN(THE CLINICAL USE OF CRYSTALLINE INSULIN*). Ann Intern Med. 1937;11:901–906. doi: 10.7326/0003-4819-11-6-901
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Published: Ann Intern Med. 1937;11(6):901-906.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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