PROTHROMBIN DEFICIENCY IN RELATION TO THE BLEEDING TENDENCY. Ann Intern Med. 1938;11:2284-2287. doi: 10.7326/0003-4819-11-12-2284
Download citation file:
Published: Ann Intern Med. 1938;11(12):2284-2287.
The essential step in blood coagulation is the change of a soluble protein-like substance, fibrinogen, to an insoluble gel called fibrin. This gel is normally rapidly formed when blood is extravasated; and under certain circumstances it may be formed intravascularly. The clotting of extravasated blood is the most important defense against undue hemorrhage. If there is a high grade defect of coagulation the patient will exhibit a bleeding tendency. The nature of such defects in the mechanism of coagulation is, therefore, a subject of intense clinical interest.
The theories of blood coagulation are notoriously complicated and unsatisfactory. There is, however,
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only