BEN FRIEDMAN; MYRON PRINZMETAL
Recent investigations have suggested that the abnormal vasoconstriction in animals and patients with persistent hypertension is due to a non-nervous and presumably chemical mechanism.1, 2, 3, 4, 5 Increased amounts of a pressor substance have been demonstrated in saline extracts made from kidneys of dogs with renal hypertension and from kidneys of patients suffering from hypertensive disease.6, 7 These observations are compatible with the hypothesis that such forms of hypertension are due to the humoral accumulation of a pressor substance of renal origin. This hypothesis would be verified by the demonstration of increased amounts of the substance in the blood
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FRIEDMAN B, PRINZMETAL M. VASOMOTOR EFFECTS OF BLOOD IN PATIENTS WITH HYPERTENSION AND ANIMALS WITH EXPERIMENTAL HYPERTENSION(VASOMOTOR EFFECTS OF BLOOD IN PATIENTS WITH HYPERTENSION AND ANIMALS WITH EXPERIMENTAL HYPERTENSION*). Ann Intern Med. 1939;12:1617–1631. doi: 10.7326/0003-4819-12-10-1617
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Published: Ann Intern Med. 1939;12(10):1617-1631.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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