ISRAEL KOPP, M.D.
The literature now contains many case reports of agranulocytosis since its first description by Schultz in 1922.1 Various hypotheses as to its etiology have been offered, and a number of drugs, nearly all containing the benzene ring, have been implicated.2, 3, 4
Agranulocytosis has been defined as a disease in which essentially there is a marked diminution or total absence of the granulocytes of the peripheral blood, which is followed by a loss of cellular resistance as shown by infectious processes of various types.4 Various other descriptive terms have been given to this syndrome, such as agranulocytic angina, primary granulocytopenia
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KOPP I. CHRONIC LEUKOPENIA WITH FATAL TERMINATION DUE TO AGRANULOCYTIC ANGINA; CASE REPORT(CHRONIC LEUKOPENIA WITH FATAL TERMINATION DUE TO AGRANULOCYTIC ANGINA; CASE REPORT*). Ann Intern Med. 1940;13:2347–2354. doi: 10.7326/0003-4819-13-12-2347
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Published: Ann Intern Med. 1940;13(12):2347-2354.
Cardiology, Coronary Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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