SAMUEL MORRISON, M.D., F.A.C.P.
In a paper on the mechanism of therapy in pernicious anemia, Greenspon1 suggested that an "extrinsic factor" as conceived by Castle was unnecessary and that an antianemic principle protected from the inactivating effect of pepsin, such as beef (or other source of "extrinsic factor") was solely essential. This suggestion coincided with our belief that antipernicious anemia potency may be attributed to the fundus as well as to other portions of the stomach, and that this potency is ordinarily neutralized by the action of pepsin, a product primarily of the fundus. Greenspon's contention if confirmed will strongly support our belief.
Learn more about subscription options.
Register Now for a free account.
MORRISON S. STUDIES IN PERNICIOUS ANEMIA: AN INQUIRY INTO THE RÔLE OF PEPSIN(STUDIES IN PERNICIOUS ANEMIA: AN INQUIRY INTO THE RÔLE OF PEPSIN*). Ann Intern Med. 1940;14:242–254. doi: 10.7326/0003-4819-14-2-242
Download citation file:
Published: Ann Intern Med. 1940;14(2):242-254.
Hematology/Oncology, Red Cell Disorders.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only