MOSES PAULSON, M.D., F.A.C.P.; CARL I. WYLER, M.D.
From time to time throughout the past years communications have appeared which have indicated that the prediction of the existence of hepatic metastasis was a possibility. In 1925 Rowntree and his associates1 using phenol tetrachlorphthalein concluded that "in the absence of clinical evidence of hepatic involvement the phenoltetrachlorphthalein test may furnish the only evidence of the existence of metastatic nodules in the liver." Positive tests were not obtained in all cases of metastatic involvement. Bargen and Rankin,2 in 1930, felt that their results, using bromsulphalein and the van den Bergh test in carcinoma of the large bowel, were statistically indicative
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PAULSON M, WYLER CI. MULTIPLE TESTS OF HEPATIC FUNCTION IN GASTROENTERIC MALIGNANCY; THE VALUE OF BROMSULPHALEIN, HIPPURIC ACID AND THE VAN DEN BERGH REACTION IN DETECTING HEPATIC METASTASIS, WITH AN EVALUATION OF NORMALITY OF THE HIPPURIC ACID TEST(MULTIPLE TESTS OF HEPATIC FUNCTION IN GASTROENTERIC MALIGNANCY; THE VALUE OF BROMSULPHALEIN, HIPPURIC ACID AND THE VAN DEN BERGH REACTION IN DETECTING HEPATIC METASTASIS, WITH AN EVALUATION OF NORMALITY OF THE HIPPURIC ACID TEST*). Ann Intern Med. 1942;16:872–878. doi: 10.7326/0003-4819-16-5-872
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Published: Ann Intern Med. 1942;16(5):872-878.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Cancer, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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