B. A. HOUSSAY; E. BRAUN-MENENDEZ; L. DEXTER
Tigerstedt and Bergmann1 described a pressor substance, renin, which is found in kidney but not in other organs and which has a prolonged pressor effect when injected intravenously. Kohlstaedt and Page2 showed that purified renin had no vasoconstrictor action when perfused through a rabbit's ear but that it became active when mixed with blood colloids. This has been corroborated by others.3 Braun-Menendez, Fasciolo, Leloir, and Muñoz4, 5, 3 identified a pressor and vasoconstrictor substance, which they called hypertensin, in the venous blood of ischemic kidneys and showed that the same substance could be obtained in vitro by incubation of renin
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HOUSSAY BA, BRAUN-MENENDEZ E, DEXTER L. THE DESTRUCTION AND ELIMINATION OF RENIN IN THE DOG(THE DESTRUCTION AND ELIMINATION OF RENIN IN THE DOG*). Ann Intern Med. 1942;17:461–473. doi: 10.7326/0003-4819-17-3-461
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Published: Ann Intern Med. 1942;17(3):461-473.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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