JOHN A. LUETSCHER JR.; SAM S. BLACKMAN JR.
Five patients with a history of recent sulfonamide medication have developed an unusual type of renal insufficiency, as well as evidence of injury to the brain. The patients presented a temporary, severe disturbance of serum sodium and chloride concentration, which was responsible, at least in part, for the death of two patients. In all cases there were signs of injury to the central nervous system, which persisted in two patients despite return of the blood chemistry to normal.
Case 1. This 25 year old colored laborer was brought to the hospital because of vomiting and delirium. His past health had
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LUETSCHER JA, BLACKMAN SS. SEVERE INJURY TO KIDNEYS AND BRAIN FOLLOWING SULFATHIAZOLE ADMINISTRATION: HIGH SERUM SODIUM AND CHLORIDE LEVELS AND PERSISTENT CEREBRAL DAMAGE(SEVERE INJURY TO KIDNEYS AND BRAIN FOLLOWING SULFATHIAZOLE ADMINISTRATION: HIGH SERUM SODIUM AND CHLORIDE LEVELS AND PERSISTENT CEREBRAL DAMAGE*). Ann Intern Med. 1943;18:741–756. doi: 10.7326/0003-4819-18-5-741
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Published: Ann Intern Med. 1943;18(5):741-756.
Emergency Medicine, Nephrology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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