PAUL S. RHOADS, M.D., F.A.C.P.; MELVIN L. AFREMOW, M.D.
In 1937 Healey1 reported that about 3 per cent of young adults being immunized against scarlet fever developed multiple joint pains as a reaction to one or more injections of the sterile filtrate of broth cultures of scarlet fever streptococci. She noted that the majority of persons who had this reaction gave a history of previous joint pains associated with rheumatic fever, or of streptococcus infections of the nose and throat. We had made similar observations. Healey showed that 74.6 per cent of a group of 63 such persons which she studied did not have joint pains when injected with
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RHOADS PS, AFREMOW ML. THE SIGNIFICANCE OF JOINT PAINS CAUSED BY STERILE STREPTOCOCCUS TOXIN(THE SIGNIFICANCE OF JOINT PAINS CAUSED BY STERILE STREPTOCOCCUS TOXIN*). Ann Intern Med. 1943;19:60–63. doi: 10.7326/0003-4819-19-1-60
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Published: Ann Intern Med. 1943;19(1):60-63.
Infectious Disease, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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