MOSES SALZER, M.D.; J. LOUIS RANSOHOFF, M.D.; BLATT HERMANN, M.D.
SALZER M, RANSOHOFF JL, HERMANN B. PRIMARY SPLENIC NEUTROPENIA, WITH REPORT OF A CASE(PRIMARY SPLENIC NEUTROPENIA, WITH REPORT OF A CASE*). Ann Intern Med. 1945;22:271-273. doi: 10.7326/0003-4819-22-2-271
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Published: Ann Intern Med. 1945;22(2):271-273.
About one year ago Wiseman and Doan1 published a report of five cases of "a hitherto unrecognized cause of neutropenia resulting from a pathologically altered, physiologic function of the normal spleen." They labelled this disease "primary splenic neutropenia." They postulated the theory that the spleen has a selective destructive action on the various cellular components of the blood. For instance, in thrombocytopenia, this selective destructive function destroyed the thrombocytes at an abnormally high rate; in hemolytic jaundice the erythrocytes were selected for destruction, whereas in "primary splenic neutropenia" the neutrophiles were the victim of this selective action. In no instance
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