RAMÓN M. SUÁREZ, M.D., F.A.C.P.; TOM D. SPIES, M.D., F.A.C.P.; RAMÓN M. SUÁREZ JR., M.D.
A number of investigators have already shown that Addisonian pernicious anemia, non-tropical sprue, and related macrocytic anemias are promptly relieved by the administration of synthetic folic acid (Lactobacillus casei factor).1, 2, 3, 4, 5, 6, 7, 8 Spies and his collaborators from Cincinnati, Birmingham, Cuba and Puerto Rico9, 10, 11 have reported a remarkable effect on persons suffering from tropical sprue. The discovery of the effect of this drug on certain types of macrocytic anemia in relapse opens up a new era in the study of anemia.
The University of Cincinnati and the School of Tropical Medicine at San Juan,
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SUÁREZ RM, SPIES TD, SUÁREZ RM. THE USE OF FOLIC ACID IN SPRUE(THE USE OF FOLIC ACID IN SPRUE*). Ann Intern Med. 1947;26:643–677. doi: 10.7326/0003-4819-26-5-643
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Published: Ann Intern Med. 1947;26(5):643-677.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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