P. W. C.
It has long been recognized that microörganisms may acquire a marked degree of resistance to a drug as a result of exposure to sublethal concentrations, although originally they were highly sensitive to its action. This phenomenon was first brought to general notice by Ehrlich nearly half a century ago in his studies of the action of arsenicals in spirochetal and trypanosomal infections. He applied the term drug-fast to such resistant strains.
In the more recent past many similar observations have been made with respect to the sulfonamides. Many highly susceptible species of organisms, such as the pneumococcus, the streptococcus and
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C. PW. ACQUIRED RESISTANCE TO ANTIBIOTICS. Ann Intern Med. 1947;27:317–319. doi: 10.7326/0003-4819-27-2-317
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Published: Ann Intern Med. 1947;27(2):317-319.
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