IRENA A. HEINDL, M.D.; BERNHARD G. ANDERSON, M.D.; RICHARD DUFFICY FRIEDLANDER, M.D., F.A.C.P.
In 1941 Rhoads and Fitz-Hugh1 described the first case of hypoprothrombinemia in which the previously accepted causes of vitamin K deficiency, i.e., liver damage and impaired intestinal absorption, seemed to play no major rôle. Thus, they established a new subgroup of the hemorrhagic disorders, namely, idiopathic hypoprothrombinemia. Since then, several similar cases2, 3, 4, 5, 6, 7, 8 have been reported, differing somewhat from one another, but all with a prolonged prothrombin time. The present case report is added to the small group already in the literature because of the dramatic response to large doses of vitamin K.
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HEINDL IA, ANDERSON BG, FRIEDLANDER RD. ACUTE IDIOPATHIC HYPOPROTHROMBINEMIA, RESPONSE TO MASSIVE DOSES OF VITAMIN K(ACUTE IDIOPATHIC HYPOPROTHROMBINEMIA, RESPONSE TO MASSIVE DOSES OF VITAMIN K*). Ann Intern Med. 1948;29:347–356. doi: 10.7326/0003-4819-29-2-347
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Published: Ann Intern Med. 1948;29(2):347-356.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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