CHARLES F. WILKINSON JR., M.D.; EUGENE A. HAND, M.D.; MAURICE T. FLIEGELMAN, M.D.
The metabolic disorder characterized by an increase of the total blood cholesterol with normal proportion of esters, and frequently an increase in the phospholipids, is designated by us as essential familial hypercholesterolemia. While this term does not follow the classifications proposed by Thannhauser,1, 2 Montgomery,3, 4 and others,5, 33, 34 it is more descriptive and useful.
While many pathological conditions have been known to be associated with xanthomatous deposits in the skin, the significance of the primary metabolic disorder has not been fully recognized. Too much emphasis has been placed on xanthoma tuberosum, xanthoma tendinosum, and xanthelasma.
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WILKINSON CF, HAND EA, FLIEGELMAN MT. ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMI(ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMI*). Ann Intern Med. 1948;29:671–686. doi: 10.7326/0003-4819-29-4-671
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Published: Ann Intern Med. 1948;29(4):671-686.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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