WARREN F. GORMAN, M.D.; EMANUEL MESSINGER, M.D.; MORRIS HERMAN, M.D.
The purpose of this article is to describe the toxic effects of thiocyanate as used in the treatment of hypertension, and to report a fatal case of thiocyanate poisoning.
The popularity of thiocyanate (SCN) treatment for hypertension has fluctuated over a period of years. The drug was first studied from a pharmacological standpoint in 1857 by Claude Bernard, but it was not until 1903 that Pauli made use of its hypotensive properties in clinical medicine. In 1925, Westphal commented on its toxic effects. In 1929, the Council on Pharmacy and Chemistry of the American Medical Association
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GORMAN WF, MESSINGER E, HERMAN M. TOXICITY OF THIOCYANATES USED IN TREATMENT OF HYPERTENSION(TOXICITY OF THIOCYANATES USED IN TREATMENT OF HYPERTENSION*). Ann Intern Med. 1949;30:1054–1059. doi: 10.7326/0003-4819-30-5-1054
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Published: Ann Intern Med. 1949;30(5):1054-1059.
Cardiology, Coronary Risk Factors, Emergency Medicine, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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