JOHN J. BUTLER, M.D.; DAVID F. JAMES, M.D.
Multiple doses of Dicumarol have frequently been reported to cause major bleeding episodes. On the other hand, it has been often emphasized1, 2 that large single doses of Dicumarol given to normal animals and human beings cause marked prolongation of the prothrombin time but do not cause bleeding.
Herein is reported a case of major bleeding following a single dose of 300 mg. of Dicumarol in a patient with poor kidney function.
A 31 year old colored female was admitted to Grady Hospital on April 22, 1948, with the chief complaint of abdominal pain. Her illness had begun
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BUTLER JJ, JAMES DF. MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROL(MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROL*). Ann Intern Med. 1950;32:731–735. doi: 10.7326/0003-4819-32-4-731
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Published: Ann Intern Med. 1950;32(4):731-735.
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