Several esters of phosphoric acid are potent inhibitors of the cholinesterase (ChE) enzymes which are present in practically all animal tissues, and, as a result, have important pharmacologic properties. Lange and von Krueger1 were the first to note the high toxicity of one group of these compounds, the alkyl fluorophosphates, which includes di-isopropyl fluorophosphate (DFP) (figure 1). The effects of DFP were found to be due to its ability to inhibit ChE enzymes irreversibly,2, 3 a property which enabled its utilization in the study of the rôle that ChE enzymes play in normal function and in disease.4 DFP has
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USES AND HAZARDS OF THE ORGANIC PHOSPHATE ANTICHOLINESTERASE COMPOUNDS. Ann Intern Med. 1950;32:1229–1234. doi: 10.7326/0003-4819-32-6-1229
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Published: Ann Intern Med. 1950;32(6):1229-1234.
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