HORACE I. CRARY; IRVING A. BECK
Acquired hemolytic anemia is a rare and chronic disease often accompanied by severe hemolytic crises. The red cell injury appears directly related to erythrocyte bound antibodies1 which may be detected by the Coombs' test.2 Numerous investigations have indicated that antibodies are produced by lymphocytes3 and possibly by the reticuloendothelial system.4 Attempts to destroy lymphoid tissue, and therefore the source of these injurious antibodies, by x-ray, nitrogen mustard and urethane, or to inhibit the reticuloendothelial system by Congo red saturation, have been of limited value.5 Splenectomy, which removes the largest lymphoid and reticuloendothelial organ in the body, has been of benefit
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CRARY HI, BECK IA. IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA TREATED BY ACTH AND CORTISONE(IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA TREATED BY ACTH AND CORTISONE*). Ann Intern Med. 1952;36:1106–1111. doi: 10.7326/0003-4819-36-4-1106
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Published: Ann Intern Med. 1952;36(4):1106-1111.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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