ARTHUR G. STEINBERG, Ph.D.; RUSSELL M. WILDER, M.D., Ph.D., F.A.C.P.
In the second edition of Darwin's The Variation of Animals and Plants Under Domestication,1 published in 1894, it is stated that the rule with respect to the age of onset of a hereditary disease in parent and child is inheritance at a corresponding period of life. It was noted, however, that "when the rule fails the disease is apt to come on earlier in the child than in the parent; the exceptions in the other direction being very much rarer." Nevertheless, investigators were finding frequent exceptions to the rule for many different diseases with a variable age of onset; and
Learn more about subscription options.
Register Now for a free account.
STEINBERG AG, WILDER RM. AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUS(AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUS*). Ann Intern Med. 1952;36:1285–1296. doi: 10.7326/0003-4819-36-5-1285
Download citation file:
Published: Ann Intern Med. 1952;36(5):1285-1296.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only