GEORGE R. MENEELY, M.D., F.A.C.P.; ROBERT G. TUCKER, Ph.D.; WILLIAM J. DARBY, M.D., Ph.D.; STEWART H. AUERBACH, M.D.
An investigation of so common a substance as salt needs an introduction. While used in abundance by nearly all of us every day, we have certainly learned the merit of restricting it in most patients with edema, and there is a growing body of evidence of its role in hypertension.1 A spate of publications on electrolytes in recent years makes one think that nothing before ever was known about salt, and there is some danger of missing the wood for the trees.
Scientific knowledge of the composition of sodium chloride did not exist earlier than 1774, when Scheele first discovered
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MENEELY GR, TUCKER RG, DARBY WJ, AUERBACH SH. CHRONIC SODIUM CHLORIDE TOXICITY: HYPERTENSION, RENAL AND VASCULAR LESIONS(CHRONIC SODIUM CHLORIDE TOXICITY: HYPERTENSION, RENAL AND VASCULAR LESIONS*). Ann Intern Med. 1953;39:991–998. doi: 10.7326/0003-4819-39-5-991
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Published: Ann Intern Med. 1953;39(5):991-998.
Cardiology, Coronary Risk Factors, Emergency Medicine, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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