DONALD D. VAN SLYKE
The manner in which tubular injury can cause excretory failure was observed by A. N. Richards in 1929.1 He watched through a microscope the nephrons of frogs that had been poisoned with sublethal doses of mercuric chloride, bichromate and other nephrotoxic poisons. Blood circulation and filtration in the glomeruli went on at a normal rate, but the entire filtrate was reabsorbed in the tubules, with resultant anuria. Richards concluded: "The only explanation which I can reach is that, under these conditions, the osmotic pressure of the blood proteins is unobstructed by the normal qualities of the tubular epithelium and is
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VAN SLYKE DD. RENAL TUBULAR FAILURE OF SHOCK AND NEPHRITIS(RENAL TUBULAR FAILURE OF SHOCK AND NEPHRITIS*). Ann Intern Med. 1954;41:709–738. doi: 10.7326/0003-4819-41-4-709
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Published: Ann Intern Med. 1954;41(4):709-738.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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