BENNETT LEVINE, M.D.; DAVID V. ROSENBERG, M.D.
Since the introduction of thiouracil for the treatment of hyperthyroidism there has been a constant search for more potent and less toxic antithyroid drugs. None of these drugs, however, is free from a variety of undesirable toxic side effects. At the present time propylthiouracil and Tapazole (1-methyl-2-mercaptoimidazole) are the drugs most frequently employed because of their proved efficacy and the relatively low incidence of toxic side reactions. Toxic reactions of all types with propylthiouracil have occurred in 1.6 to 3.2 per cent of cases.1-4 Severe leukopenia and agranulocytosis have occurred in 0.5 to 1.0 per cent of patients,2-9 and several
Learn more about subscription options.
Register Now for a free account.
LEVINE B, ROSENBERG DV. APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLE(APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLE*). Ann Intern Med. 1954;41:844–848. doi: 10.7326/0003-4819-41-4-844
Download citation file:
Published: Ann Intern Med. 1954;41(4):844-848.
Endocrine and Metabolism, Hematology/Oncology, Red Cell Disorders, Thyroid Disorders.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only