BERNARD STRAUS, M.D., F.A.C.P.; JULIUS EISENBERG, M.D.; JOSEPH GENNIS, M.D., F.A.C.P.
It is widely recognized that one of the important side effects of the antihistamines as a class is their sedative action; it has also been considered the most characteristic.1 Controlled studies of their hypnotic (sleep-inducing) effect, however, are lacking. This side effect may be either desirable or objectionable, depending on the situation in which the drug is employed. It was obvious that such a side effect might be used to good advantage as a primary action, i.e., the use of antihistamines as hypnotics. This would seem to be of some value, since the toxicity of this class of compounds is
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STRAUS B, EISENBERG J, GENNIS J. HYPNOTIC EFFECTS OF AN ANTIHISTAMINE—METHAPYRILENE HYDROCHLORIDE(HYPNOTIC EFFECTS OF AN ANTIHISTAMINE—METHAPYRILENE HYDROCHLORIDE*). Ann Intern Med. 1955;42:574–582. doi: 10.7326/0003-4819-42-3-574
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Published: Ann Intern Med. 1955;42(3):574-582.
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