WESLEY W. SPINK, M.D., F.A.C.P.
In their initial reports upon the effects of corticotropin and cortisone in patients having rheumatoid arthritis or rheumatic fever, Hench and his associates1, 2 emphasized two manifestations: inflammation of the tissues was subdued, and the patients experienced a remarkable sense of well-being. Soon thereafter, extensive observations were made by others3, 4, 5 in human subjects having a variety of infections, and in experimentally infected animals. It was demonstrated in patients with pneumococcal pneumonia that the administration of ACTH caused a crisis and striking improvement, although pneumococci persisted in the tissues for many days.6 On the other hand, it was also
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SPINK WW. ADRENOCORTICOTROPIC HORMONE AND ADRENAL STEROIDS IN THE MANAGEMENT OF INFECTIOUS DISEASES(ADRENOCORTICOTROPIC HORMONE AND ADRENAL STEROIDS IN THE MANAGEMENT OF INFECTIOUS DISEASES*). Ann Intern Med. 1955;43:685–701. doi: 10.7326/0003-4819-43-4-685
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Published: Ann Intern Med. 1955;43(4):685-701.
Adrenal Disorders, Endocrine and Metabolism, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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