J. GRAHAM SMITH JR., M.D.
A case of clinically recognizable progressive bacterial synergistic gangrene was reported as early as 1909.1 Two other cases were reported in 1924,2, 3 but it was not until 1926 that Meleney clearly demonstrated the etiology of the infection.
Bacteriologic studies4 were made by Meleney on the lesion of a patient who had developed a progressive gangrene of the abdominal wall following the surgical drainage of an appendiceal abscess. A micro-aerophilic nonhemolytic streptococcus was cultured from far out in the spreading periphery of the lesion. Micrococcus pyogenes var. aureus (hemolytic Staphylococcus aureus) and diphtheroid bacilli were cultured from the
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SMITH JG. PROGRESSIVE BACTERIAL SYNERGISTIC GANGRENE: REPORT OF A CASE TREATED WITH CHLORAMPHENICOL(PROGRESSIVE BACTERIAL SYNERGISTIC GANGRENE: REPORT OF A CASE TREATED WITH CHLORAMPHENICOL*). Ann Intern Med. 1956;44:1007–1015. doi: 10.7326/0003-4819-44-5-1007
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Published: Ann Intern Med. 1956;44(5):1007-1015.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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