ROBERT E. BOLINGER, M.D., F.A.C.P.; MAHLON H. DELP, M.D., F.A.C.P.
Since the original descriptions of Cushing's disease as a form of pituitary basophilism,1, 2 the emphasis has gradually shifted so that the adrenal cortex is now known to be essential for the genesis of the syndrome.3, 4, 5 The exact role which the pituitary or the hypothalamus6, 7 may play is in some doubt, and therapeutic approaches directed at other than the adrenal cortex, such as pituitary irradiation2 and androgens,8, 9 have been disappointing. Satisfactory remissions after surgical resection of the adrenal glands have, however, been reported by Collett,10 Walters et al.,4 Walters and Kepler,11 Walters12 and Cope and Raker.13
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BOLINGER RE, DELP MH. MEDICAL CONSIDERATIONS IN ADRENAL SURGERY(MEDICAL CONSIDERATIONS IN ADRENAL SURGERY*). Ann Intern Med. 1957;46:662–677. doi: 10.7326/0003-4819-46-4-662
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Published: Ann Intern Med. 1957;46(4):662-677.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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