JOHN E. MIDDLEBROOK, M.D.
Hypofibrinogenemia has been recognized more frequently in recent years. Congenital afibrinogenemia, a condition caused by a congenital defect in the enzyme system responsible for fibrinogen production, has been recognized for many years. Acquired afibrinogenemia has been observed as a complication of shock,1 severe liver damage associated with a septic abortion and bacteremia,2 pulmonary surgery,3 severe tissue damage,4 inadequate protein intake,5 thrombotic thrombocytopenic purpura,6 polycythemia,7 and the various complications of pregnancy, including abruptio placentae, intra-uterine death, and amniotic fluid embolism.8, 9, 10 Acquired hypofibrinogenemia has also been observed in association with various malignant growths, including carcinoma of the prostate,11, 12 pancreas13,
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MIDDLEBROOK JE. HYPOFIBRINOGENEMIA WITHOUT FIBRINOLYSIS ASSOCIATED WITH A LYMPHOMA AND CONTROLLED AFTER TREATMENT WITH CORTISONE AND NITROGEN MUSTARD(HYPOFIBRINOGENEMIA WITHOUT FIBRINOLYSIS ASSOCIATED WITH A LYMPHOMA AND CONTROLLED AFTER TREATMENT WITH CORTISONE AND NITROGEN MUSTARD*). Ann Intern Med. 1957;47:1242–1251. doi: 10.7326/0003-4819-47-6-1242
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Published: Ann Intern Med. 1957;47(6):1242-1251.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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