R. M. BECKER, M.D., F.A.C.P.
A previous report1 described the in vivo action of penicillinase on circulating penicillin in guinea pigs and human subjects without reactions. The following is a report of the clinical effectiveness of penicillinase in humans with penicillin reactions.
Penicillinase2 is an enzyme specific for its substrate penicillin. Its inactivating action against penicillin has been utilized for years in the clinical laboratory in bacteriologic media to inhibit penicillin in body fluids to be cultured. Penicillinase can be obtained from several strains of bacteria, including staphylococci and Escherichia coli. Commercially it is produced in greatest abundance from cultures of Bacillus cereus, strain NRRL-B
Learn more about subscription options.
Register Now for a free account.
BECKER RM. A NEW CONCEPT IN THE TREATMENT OF PENICILLIN REACTIONS: USE OF PENICILLINASE(A NEW CONCEPT IN THE TREATMENT OF PENICILLIN REACTIONS: USE OF PENICILLINASE*†)(A NEW CONCEPT IN THE TREATMENT OF PENICILLIN REACTIONS: USE OF PENICILLINASE*†). Ann Intern Med. 1958;48:1228–1242. doi: 10.7326/0003-4819-48-6-1228
Download citation file:
Published: Ann Intern Med. 1958;48(6):1228-1242.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only