ALF S. ALVING; ROBERT W. KELLERMEYER; ALVIN TARLOV; STANLEY SCHRIER; PAUL E. CARSON
Acute hemolysis, which may destroy half the red cells within a few days, occurs in approximately 10% of otherwise healthy American Negroes, very rarely in Caucasians,1, 2, 3 when 30 mg. primaquine base (twice the dose necessary to cure vivax malaria) are administered daily. Hemolysis is self-limited and is a function of cell age, the older cells being the more susceptible.4, 5 Sensitivity to the drug has a familial distribution.6 The erythrocytes of sensitive individuals are normal morphologically, and no abnormal erythrocyte antibodies have been detected.7, 8 Sensitive individuals react similarly to ingestion of a growing number of agents, including
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ALVING AS, KELLERMEYER RW, TARLOV A, SCHRIER S, CARSON PE. BIOCHEMICAL AND GENETIC ASPECTS OF PRIMAQUINE-SENSITIVE HEMOLYTIC ANEMIA(BIOCHEMICAL AND GENETIC ASPECTS OF PRIMAQUINE-SENSITIVE HEMOLYTIC ANEMIA*). Ann Intern Med. 1958;49:240–248. doi: 10.7326/0003-4819-49-2-240
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Published: Ann Intern Med. 1958;49(2):240-248.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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