DANIEL N. MOHLER, M.D.; BYRD S. LEAVELL, M.D., F.A.C.P.
Since Ehrlich's1 original description of aplastic anemia in 1888, many names have been applied to this type of anemia: bone marrow failure,2 aleukia hemorrhagica,3 aregenerative anemia,3 panmyelophthisis,3 marrow insufficiency,4 toxic paralytic anemia,5 progressive hypocythemia,6 hypoplastic anemia,7 refractory anemia8 and adynamic anemia.9 The Committee for Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming Organs10 has recommended the term "hypoplastic normocytic or macrocytic anemia, due to unknown cause."
None of the suggested names is entirely satisfactory. The chief objection to the term "aplastic anemia" is the fact, first pointed out by Blumer11 in 1905 and later
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MOHLER DN, LEAVELL BS. APLASTIC ANEMIA: AN ANALYSIS OF 50 CASES(APLASTIC ANEMIA: AN ANALYSIS OF 50 CASES*). Ann Intern Med. 1958;49:326–362. doi: 10.7326/0003-4819-49-2-326
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Published: Ann Intern Med. 1958;49(2):326-362.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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