ROBERT P. ARTHUR, M.D.; WALTER B. SHELLEY, M.D., F.A.C.P.
The purpose of this paper is to present a controlled study of pruritus in dermatitic skin. Recent experimental work has greatly enlarged our knowledge of this troublesome sensation in normal human subjects. A summary of this work will explain the new testing methods developed for use in this report, as well as provide a background understanding of itching mechanisms and responses.
Until recently, histamine was the standard material for experimentally inducing a measurable pruritus. The patient's sensitivity was determined by finding the threshold dilution. Indeed, many workers, following Sir Thomas Lewis, considered histamine as the probable direct chemomediator of
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ARTHUR RP, SHELLEY WB. THE NATURE OF ITCHING IN DERMATITIC SKIN(THE NATURE OF ITCHING IN DERMATITIC SKIN*). Ann Intern Med. 1958;49:900–908. doi: 10.7326/0003-4819-49-4-900
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Published: Ann Intern Med. 1958;49(4):900-908.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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