JAMES M. MOSS, M.D., F.A.C.P.; DEWITT E. DELAWTER, M.D.; JOHN J. CANARY, M.D.
Satisfactory control of diabetes mellitus has been reported in more than half of the patients treated with tolbutamide.1, 2, 3 After an initial period of good response a few patients develop persistent hyperglycemia unresponsive to an increased dose. This secondary failure to respond has been reported in 0.3%4 to 14%5 of all patients. The incidence may be higher when more patients have been followed for a longer period of time. The records of 200 tolbutamide-treated patients have been reviewed in an effort to evaluate this and other problems.
The patients in the early part of this series
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MOSS JM, DELAWTER DE, CANARY JJ. THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILURE(THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILURE*†)(THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILURE*†). Ann Intern Med. 1959;50:1407–1417. doi: 10.7326/0003-4819-50-6-1407
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Published: Ann Intern Med. 1959;50(6):1407-1417.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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