VERONICA HALMOS, M.D., F.R.C.P.(C); ROBERT VOLPÉ, M.D., F.R.C.P.(C)
This communication reports a patient with coincident myxoedema and pernicious anaemia, who subsequently developed polycythaemia when therapy was instituted for the two diseases.
The clinical similarities of pernicious anaemia and myxoedema (1, 2) and their occasional coexistence (2-7) have long been noted. Although a non-megaloblastic macrocytic anaemia which responds only to thyroid therapy is frequently observed in myxoedema (3, 8, 9), there are now well-authenticated case reports in which true pernicious anaemia and myxoedema were coexistent (3-7). The anaemic states in these patients did not respond to thyroid therapy until liver or vitamin B12 therapy had been added. It should
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HALMOS V, VOLPÉ R. Coincidental Myxoedema and Pernicious Anaemia with Subsequent Development of Polycythaemia after Vitamin B12 Therapy. Ann Intern Med. 1961;55:301–306. doi: 10.7326/0003-4819-55-2-301
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Published: Ann Intern Med. 1961;55(2):301-306.
Endocrine and Metabolism, Hematology/Oncology, Red Cell Disorders, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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