LLOYD T. ISERI, M.D., F.A.C.P.; ETELE L. BALATONY, M.D.; JOHN R. EVANS, M.D.; MILTON G. CRANE, M.D.
The exact mechanism of sodium and water retention in congestive heart failure remains obscure despite the fact that hemodynamic, circulatory, renal, and endocrine factors have been studied extensively. Metabolic studies (1-7) have suggested that certain changes occur in the tissue cells which might be responsible for the ultimate accumulation of salt and water. Electrolyte studies of the plasma in heart failure (8, 9) have concurred indirectly with the hypothesis that circulatory insufficiency produces increased cellular osmolality. In view of these changes, further study of the effect of circulatory stress on the extracellular compartment seemed to be indicated.
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ISERI LT, BALATONY EL, EVANS JR, CRANE MG. Pathogenesis of Congestive Heart Failure: Effect of Posture and Exercise on Plasma Volume and Plasma Constituents. Ann Intern Med. 1961;55:384–394. doi: 10.7326/0003-4819-55-3-384
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Published: Ann Intern Med. 1961;55(3):384-394.
Cardiology, Heart Failure.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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