ANN A. BROWDER, M.D.; JOHN W. HUFF, M.D.; ROBERT G. PETERSDORF, M.D.
Fever is often a manifestation of neoplastic disease, and the literature is replete with case reports of patients who were febrile for months and even years before exhaustive investigation revealed a cryptic neoplasm. Hypernephroma is the prototype of tumor frequently associated with fever and is described in several series of patients with fever of unknown etiology (1-3). Actually, however, fever is a relatively rare symptom of renal cell carcinoma. Israel (4) reported that only 8.2% of 146 patients with hypernephroma were febrile, and Soloway (5) noted pyrexia in eight among his 130 patients. Among 273 patients with renal neoplasms reported
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BROWDER AA, HUFF JW, PETERSDORF RG. The Significance of Fever in Neoplastic Disease. Ann Intern Med. 1961;55:932–942. doi: 10.7326/0003-4819-55-6-932
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Published: Ann Intern Med. 1961;55(6):932-942.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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