YORK E. CRAWFORD, M.S.; M. J. MCNAMARA
Although a group A streptococcal infection is recognized as being important in the pathogenesis of acute rheumatic fever, the precise role of the causative bacteria remains poorly understood. One finding has been commonly noted, namely, that streptococcal antibodies tend to rise to higher titer in rheumatic fever than in uncomplicated streptococcal infection (1-6). This observation has suggested that antigen-antibody interreaction is a factor in the pathogenesis of acute rheumatic fever (7, 8). A question often posed is whether or not subjects who develop rheumatic fever are immunological hyperreactors who will respond excessively to any antigenic stimulation.
Creger, Choy, and Rantz
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CRAWFORD YE, MCNAMARA MJ. The Antibody Response of Rheumatic Fever Subjects to Respiratory Viruses. Ann Intern Med. 1962;56:389–396. doi: 10.7326/0003-4819-56-3-389
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Published: Ann Intern Med. 1962;56(3):389-396.
Infectious Disease, Rheumatology, Streptococcal Infections.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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